Legg-Calve-Perthes Disease comprises a specific childhood condition that impacts the hip. The disorder happens on account of temporary disruption of the blood supply into the femur’s roundhead. Without a sufficient blood supply, there is the death of the bone cells in a process called avascular necrosis. Fortunately, CBD could be a perfect supplement to assist with the regeneration of fresh bone during the fragmentation and reossification periods of Perthes Disease. It also helps with the pain and inflammation associated with the disease.
What Is Legg-Calve-Perthes Disease
Legg-Calve-Perthes disease (LCPD) comprises a category of disorders termed as the Osteochondroses. The osteochondroses usually are marked by decline and subsequent regeneration of the developing end of a bone (epiphyses). In LCPD, the developing end of the top portion of the thigh bone (femur) is impacted. The top section of the thigh bone is called the head or the “ball” and joins to the hip in a depression or “socket”. This comprises the hip joint, which constitutes a ball and socket joint. The disorder arises from an unknown stoppage of the blood supply (ischemia) to the head of the femur, which causes decay (avascular necrosis) and disfigurement of the femoral head.
Symptoms may comprise a limp with or without pain in the knee, thigh, hip, or groin, muscle spasms, and restricted movement of the affected hip.
The disease process appears to be self-restricting as fresh blood supplies are built (revascularization) and new healthy bone develops (re-ossifies) in the impacted area. The precise cause for the temporary stoppage of blood flow to the femoral epiphysis is not completely known. Most cases seem to happen randomly for no obvious reason or sporadically.
Causes Of Legg-Calve-Perthes Disease
Legg-Calve-Perthes disease happens when too less blood is delivered to the ball portion of the hip joint or femoral head. Without a sufficient blood supply, this bone gets unstable, and it may split easily and heal badly. The underlying cause of the temporary decrease in blood flow to the femoral head is still unclear. Some latest studies show that there might be a genetic connection to the growth of Perthes, though more research is required.
Symptoms Of Legg-Calve-Perthes Disease
Children with LCPD may feel:
- Hip pain generally only on one side
- Pain within the thigh, knee, or groin (rather than in the hip) that may happen as “referred” pain from the hip due to nerves in the leg
- Restricted movement in the hip
- Muscle spasms
- Limping without a clear cause (like an injury) that stays for several days
- Feebleness And Muscle Wasting at a further stage of the disease process
How CBD Is Helpful For Legg Calve Perthes Disease
CBD aids to alleviate the symptoms of Legg Calve Perthes disease due to its anti-inflammatory, pain-relieving, antispasmodic and bone healing properties.
Helps To Alleviate Pain
A prominent way CBD helps to relieve pain is by preserving Anandamide, an endogenous cannabinoid normally present in our body also termed bliss molecule. CBD on accessing the endocannabinoid system prevents anandamide from disintegration too quickly, by joining to the proteins that split up this bliss molecule. Thereby, CBD aids anandamide to stay in the system longer, which allows the ECS to control more effectively.
CBD also aids to relieve pain by modulating and controlling endorphins. Endorphins are the feel-nice chemicals available in the body that aid with pain. CBD assists to elevate our internal endorphins naturally, eliminating the risk of dependence on Opioids and synthetic drugs.
Aids To Alleviate Inflammation
The anti-inflammatory properties of CBD aid to control the inflammation due to Legg-Calve-Perthes disease. The body when irritated sends a group of invading immune cells to the area to remove any pathogens that may be injuring your body. Excess inflammation can aggravate the problem wherein CBD can help. CBD elevates the endocannabinoid 2-AG that reduces the number of immune cells discharged.
CBD aids to relieve the nerves and the damaged joints and reduces the soreness and inflammation by lowering the production of pro-inflammatory cells termed cytokines. It is a fact that pain accompanies inflammation. cytokines play an integral role in pain resulting from injuries or pathologic pain by stimulating the pain receptors in the neurons.
When CBD attaches to the CB2 receptors of the immune cells that are overactive, it stimulates a particular type of anti-inflammatory protein known as caspase. When the caspase becomes stimulated, it dispatches a signal that results at the beginning of the process of immune cell death or apoptosis. As there is the death of immune cells by stimulation of caspase, the inflammatory process gets regulated with a reduction in cytokine production.
Promotes Healing Of Fractures
Cannabinoid therapy has also been indicated to aid in bone fragment healing by enhancing the volume and thickness of trabecular bone and the availability of unabsorbed cartilage. CBD has shown to increase the strength of healed femurs and also provides therapeutic value in spinal cord injuries by lessening the loss of bone mineral that leads to these injuries.
Improves Bone Healing
Cannabinoid receptors had been earlier shown to stimulate bone formation. The researchers observed that CBD advanced bone healing by fortifying the cartilage bridge that forms during the repairing of a bone. This bridge is termed the fracture callus, it’s composed of collagen that then slowly mineralizes and solidifies into the fresh bone.
CBD was also displayed to enhance fracture healing by stimulation of Lysyl Hydroxylase, a primary enzyme that is directly involved in bone healing and is present in all bone-healing cells (known as osteoblasts). This activation kick-started osteoblast cells during the process of healing, promoting the healing process and making collagen cells to build stronger, healthier bones while the fracture is healing.
Numerous people having Legg-Calve-Perthes disease continue to build a painful joint disorder termed osteoarthritis within the hips while young. CBD may help with this condition.
Conclusion On CBD For LCPD
Apart from being anti-inflammatory, which would be beneficial for the early onset of the disease, studies show that CBD activates Lysyl Hydroxylase Collagen (a highly rich enzyme engaged in bone healing) activity in osteoblasts (bone forming cells). This is a near perfect therapy for Perthes Disease and in the absence of medicines to heal the bones in the disease presently; it all is left to happen naturally. The sole medicines provided are painkillers for connected pain like knee and hip pain. Thus, CBD can go a long way in helping with the management of this disorder.