Various genres of kidney ailments like diabetic nephropathy, chronic kidney disease arising from high blood pressure or impact on the kidney tissue due to ailments or the immune system like glomerulonephritis, nephropathy or polycystic kidney disease can lead to kidney failure if improperly treated. The inherited kidney disorder, Polycystic kidney disease (PKD) results in chronic kidney ailment which with the advancement of time result in reduced kidney performance and eventual failure. However, managing the symptoms of PKD like blood pressure, UTI infections and frequent micturition with the major cannabinoid derived from the hemp plant, CBD can offer therapeutic benefits in treating kidney ailments.
What Polycystic Kidney Disease Is All About
Polycystic kidney disease is a genetic ailment that results in the development of clusters of cysts inside the kidneys. The cysts contain a fluid which can cause an enlargement of the kidneys and replacing their normal structure. The abnormal size of the kidneys and its shape causes chronic kidney disease. Generally, most cysts grow in the kidneys, but PKD cysts also tend to grow inside the liver and other areas across the body.
The Cause Behind Polycystic Kidney Disease (PKD)
The main cause behind PKD has inherited a genetic disorder. In unique cases, a mutated gene also gives rise to this disease. The two kinds of polycystic kidney disease arising out of genetic defects are autosomal dominant polycystic kidney disease (ADPKD), where only a single parent has the abnormal gene. Another lesser regular kind of PKD is Autosomal recessive polycystic kidney disease (ARPKD) that arises immediately after birth or at childhood. The abnormal genes are present in both the parents for this kind of disease.
Symptoms Associated With Polycystic Kidney Disease
PKD brings with it a litany of symptoms that needs to be attended immediately. Some of the signs of PKD include:
- High blood pressure
- Back pain or side aches
- Blood in urine
- An enlargement of abdomen size
- Recurrent urination
- Kidney stones
- Infection in the urinary tract or kidneys
Other symptoms from this ailment also include brain aneurysms, defects of the heart valve, colon disorders, and chronic pain.
Though no cure is available for PKD, modifications in lifestyle and medical therapy can assist in lowering kidney impairment and regulate blood pressure. You can delay the advancement of the ailment by managing high blood pressure and taking medications for chronic pain. However, additional therapy is mandatory if infections of the bladder or kidney, aneurysms or blood in the urine develop. One such natural alternative with no adverse side effects is the phytocannabinoid CBD which is highly effective in blood pressure regulation and chronic pain management.
Effects CBD Has On Polycystic Kidney Disease
Cannabidiol (CBD) has been found in preclinical studies to beneficially reduce oxidative stress, swelling, and kidney cell death and enhancing the renal function which made the researchers conclude about its effectiveness in curing kidney disease. This plant compound can be useful in treating polycystic kidney disease in the following ways:
Activates The Endocannabinoid System
CBD works upon the cannabinoid receptors CB2 of the endocannabinoid system and stimulates them which is found in a study to be effectual in safeguarding the kidney from impairment by reducing inflammation and oxidative stress.
Lowers Blood Pressure
CBD helps to limit kidney impairment resulting from polycystic kidney disease by substantially reducing blood pressure. Both human and animal pieces of research have revealed the vasodilatory effects of cannabinoids on blood vessels which aid in improving blood flow and lowering blood pressure. CBD specifically was found by researchers to provide vasodilation which permitted higher blood flow and decreased damage.
Efficient Management Of Pain
A well-known analgesic, CBD can assist polycystic kidney disease sufferers, handle their levels of chronic pain. CBD has been found to substantially reduce both neuropathic and nociceptive pain and chronic pain that has previously proved to be refractory to various therapies. Besides, it also plays a therapeutic role in treating migraines and headaches which are frequent in sufferers of Polycystic kidney disease.
Vested With Anti-tumoral Properties
CBD can reduce the size of tumors and can cause cell death with nil neurotoxic effect. Moreover, the association between endocannabinoid receptors and tumor cells has widened the scope of antitumor actions performed by cannabinoids and its application as antitumor agents. Cannabidiol can be applied to restrict the migration of tumor cells and the formation of blood vessels inside tumors.
Manages Urinary Tract Infections
Urinary tract infections (UTI) if not properly addressed can result in kidney damage and failure. Women are more prone to such infection. The antimicrobial and antibacterial attributes of CBD assists in fighting UTI problems. Besides, CBD can also lower the inflammation of the urinary tract by controlling the immune function which helps to combat the source of the inflammation.
Conclusion On CBD In Polycystic Kidney Disease
The miracle compound CBD acts as a deterrent in the progress of kidney disease and efficiently manages the symptoms of chronic kidney disease whether arising from immune system disorder, genetic or diabetes. By stabilizing blood sugar, decreasing nerve inflammation and neuropathic pain and minimizing high blood pressure CBD has a positive effect on renal function in different types of kidney disorders including polycystic kidney disease.