The less abundant phytocannabinoid, CBG is evoking growing interest due to its pharmacological features. Similar to CBD and THC, it occurs as cannabigerolic acid (CBGA) inside the plant and gets decarboxylated to CBG through light, heat and time. The role of cannabinoids for the therapy of gastrointestinal symptoms such as vomiting, nausea, and visceral pain (pain that emanates from within/surrounding organs) was examined and discovered that various targeted cannabinoid treatments may be helpful in GI disease control.

Effects Of Cannabinoid Upon The GI System

Research shows that the modulation of the endocannabinoid system (particularly the kind of cannabinoid receptor present most frequently within the gastrointestinal system, called CB1 receptors) may control:

  • Intake of food
  • Secretion in the stomach (acid is released by the stomach cells to digest food)
  • Ion exchange (absorption and discharge – keeping correct fluid/electrolyte (such as salt) balance)
  • GI motility (excessive movement – diarrhea, too less movement – constipation)
  • Protection of stomach (an unprotected stomach can be harmed by the acidic discharge)
  • Sensation in an internal organ
  • The process of inflammation that develops from certain GI ailments
  • The number of cell in the GI tract (excess of cells is indicative of cancer or a disease process, too few might cause tissue injury)


It was also observed that the modulation of a different cannabinoid receptor (CB2) commonly occurring in the immune system cells can aid:

  • Control motility
  • Regulate the inflammation procedure emanating from some GI disorders
  • In decreasing sensation and internal pain

Abdominal Pain And Stomach Ache

A stomach ache frequently denotes cramps or a dull ache within the tummy (abdomen). It’s generally short-lived and frequently not serious.


Acute abdominal pain constitutes a greater reason for concern. When it begins suddenly and unsuspectingly, it must be considered a medical emergency, particularly when the pain is focussed in a specific region.


Serious reasons for sudden acute abdominal pain comprise appendicitis, acute cholecystitis, kidney stones, and diverticulitis. Infection within the stomach and bowel (gastroenteritis) may also cause unexpected and severe abdominal pain. It might also result from a pulled muscle within your abdomen or through an injury.


Adults may experience it due to IBS, IBD, a urinary tract infection, period pain in women, and other stomach-based issues like heartburn, stomach ulcer, and gastritis.

How CBG Helps To Treat Stomach Aches

Cannabigerol (CBG) has a certain affinity for CB1 and CB2 receptors, besides possessing strong antispasmodic abilities as it can restrict reuptake of the neurotransmitter GABA more as compared to CBD and THC.


CBG also possesses stronger anti-inflammatory and analgesic properties as against THC, allowing it to obstruct the lipoxygenase inflammatory channel and lessen swelling. Elevating GABA levels affords another mechanism which supports pain alleviation, as numerous neurons within the spinal cord area concerned with pain transfer are responsive to GABA, that is an inhibitory neurotransmitter.


Since CB2 receptors are located heavily within the GI system (Gastrointestinal system), they are responsible for tempering inflammatory responses. This is the primary reason why stomach ache is benefitted by cannabinoid treatment like CBG. By targeting itself on the molecules that lead to inflammation CBG can heal stomach aches, IBD and gastrointestinal disorders.


The anti-tumoral property of CBG inhibits the growth of cancer cell and triggered programmed cell destruction in human colon cancer cells, and stomach cancer cells. CBG also exhibits anti-bacterial properties against different bacterial strains. Another study displayed CBG reduces mouse and human bladder contractility which was not through the CB1 or CB2 receptor.


In view of the safety profile of endocannabinoid modulation and phytocannabinoids like CBG and the disabling nature of different GI disorders and stomach aches, greater research into their control by using various cannabinoids is warranted. More research will assist to determine what GI disorders, ailments, and symptoms cannabinoid treatments might be helpful for and the type of cannabinoid treatment that is suited for each situation.
The review indicates that cannabinoids such as CBG possess the potential to perform a key role in the modulation of vomiting, stomach aches, and probably visceral pain. Though the jury is still engaged in determining the “magic drug,” it appears that with the evolution of latest ligands (agents that join to receptors, like cannabinoids), the future looks promising.

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